CNS Drug Reviews
نویسندگان
چکیده
Monoamine oxidase (MAO) is an enzyme that metabolizes a wide range of monoamines and is important in the control of the concentration of these neurotransmitters. Several reports have shown that stress can decrease MAO inhibitory activity. An endogenous MAO inhibitory component was first discovered in normal human urine by Glover et al. (22), and the compound responsible for the MAO activity was subsequently named tribulin (51). In 1988, isatin was identified as a major constituent of tribulin, a low-molecular-weight inhibitor of MAO type B (MAO-B) (20). We isolated and identified isatin in the urine (25) and the brain (26) of stroke-prone spontaneously hypertensive rats (SHRSP) (Fig. 1.) Tribulin output in human urine increases during various conditions of stress and anxiety (14). Cold immobilization stress, for example, has been associated with the serotonergic system (47). Cold restraint stress increases tribulin in the rat heart and kidney (3). Tribulin acts on central benzodiazepine receptors, and has been proposed to be an anxiety-promoting agent (51). The potency of the MAO inhibitory and benzodiazepine-re-
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